en فیزیولوژی ورزشی Sport Physiology تحقيقي Original Paper <strong>Background and objectives: </strong>Cardiovascular disease is one of the most important causes of mortality worldwide. The present study aimed to compare two different cardiac rehabilitation protocols on ATP-binding cassette sub-family G member 1 (ABCG1) lymphocyte expression and blood lipid profile in middle-aged men undergoing coronary artery bypass grafting.<br> <strong>Methods: </strong>Forty five middle-aged men who had previously undergone coronary artery bypass surgery were randomly divided into three groups of control (C; n=15), aerobic training (AT; n=15) and combined training (CT; n=15). Blood samples were taken before the first and after the last exercise sessions. After isolation of mononuclear cells using Ficoll and mRNA purification, gene expression changes were examined by real-time PCR. Data were analyzed using one-way ANOVA and Bonferroni post-hoc tests.<br> <strong>Results: </strong>Eight weeks of training intervention resulted in a significant increase in ABCG1 expression as well as a significant decrease in plasma levels of LDL, triglyceride and total cholesterol in both training groups. However, there was no significant difference between the AT and CT groups. In addition, high-density lipoprotein was significantly increased in the AT and CT groups.<br> <strong>Conclusion: </strong>Both AT and CT can increase plasma LDL and increase ABCG1 expression and HDL concentrations, indicating the positive effects of both interventions on the prevention of atherosclerosis. Coronary Artery Bypass,Circuit-Based Exercise,ABCG1,Exercise, 28 34 http://mlj.goums.ac.ir/browse.php?a_code=A-10-597-10&slc_lang=en&sid=1 Rokhsareh Moosavi Rokhsareh.Mousavi@yahoo.com 100319475328460019124 100319475328460019124 No Islamic Azad University, Neyshabur Branch, Neyshabur, Iran Amir Rashidlamir Rashidlamir@um.ac.ir 100319475328460019125 100319475328460019125 No Ferdowsi University of Mashhad Rambod Khajeie r.khajeie@gmail.com 100319475328460019126 100319475328460019126 Yes Islamic Azad University, Neyshabur Branch, Neyshabur, Iran Mahmoud Hejazi Sm.hejazi37@gmail.com 100319475328460019127 100319475328460019127 No Ferdowsi University of Mashhad