Medical Laboratory Journal

fa Effect of Eight Weeks Aerobic and Combined Training on Serum Levels of Sirtuin 1 and PGC-1α in Coronary Artery Bypass Graft Patients تحقيقي Original Paper <div>ABSTRACT            Background and objectives:  Sirtuin-1 (SIRT1) is a conserved a NAD+-dependent protein deacetylase essential for cellular metabolism and defence against oxidative stress and endothelial dysfunction. This study aimed to compare effects of 8 weeks of aerobic and combined training on serum level of SIRT1 and PGC1-α in coronary artery bypass graft patients.            Methods: In this semi-experimental study, 45 non-active men (mean age 47.4 ± 3.3 years) who had undergone coronary artery bypass graft surgery were randomly divided into three groups: aerobic training, combined resistance and aerobic training and control. Trainings were performed at 80% of maximum heart rate, three sessions a week for 8 weeks. Blood samples were collected 24 hours before the first exercise session and 48 hours after the last training session. T-test and one-way analysis of variance were used for assessment of within-group and between-group differences, respectively. P-values less than 0.05 were considered as statistically significant.            Results: The 8-week aerobic and combined training increased serum levels of SIRT1 and PGC-1α compared with the control group, and significantly decreased the weight of subjects (p=0.001). There was no significant difference in serum levels of SIRT1 and PGC-1α between the two training groups (P≥0.05).            Conclusion: Both combined and aerobic training significantly improve the SIRT1 and PGC-1α levels in coronary artery bypass graft patients.            KEYWORDS: Combined training, Aerobic training, PGC-1α, SIRT1, CABG patient.</div> Combined training, Aerobic training, PGC-1α, SIRT1, CABG patient. 50 56 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1-543&slc_lang=fa&sid=1 Najmatol Sabah Alavizadeh 100319475328460015354 100319475328460015354 No Student of Sports Physiology, Islamic Azad University of Neyshabour, Neyshabour, Iran Amir Rashidlamir rashidlamir@um.ac.ir 100319475328460015355 100319475328460015355 Yes Department of Sports Physiology, Faculty of Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran Seyed Mahmood Hejazi 100319475328460015356 100319475328460015356 No Department of Sports Physiology, Faculty of Sports Sciences, Islamic Azad University of Mashhad, Mashhad, Iran